A colonizing armada of interstellar-traveling sentient-insects arrives in the Sol system. They have their eyes on Earth, with its billions of humans and other species, which to them are simply protein on foot, paw or hoof. A place to spend the next few centuries grazing and reproducing before moving on to another system once the protein is gone.
An unknown enemy of the bugs sends a message to Earth, intercepted by SETI, that describes a “gift to mankind” left beneath the South Pole long ago. A series of mysterious blue meteorites are found there that grant astounding strength and power, even flight, to a select group of humans who have just the right gene sequence, passed down for thousands of years in their maternal line. All of them female.
These so-called Ubers organize and wage war against the bugs, supported by all the Normals on Earth. After the bugs make a horrific attack on Earth, the Rocinate and its small crew of Ubers along with one man, Captain John Phillips, search for the heart of the bug armada so as to destroy its Queens before they can reach Earth and begin to reproduce.