Karen Starr appears in the first issue of Mister Terrific -- which I guess is an appropriate venue, seeing that she and Michael Holt are both C.E.O's of cutting-edge tech companies.
There's no mention of her being Power Girl, she doesn't appear in costume, and she doesn't display any super-powers -- so PG's status in the new DC universe is still unclear. But at least she has a toehold in the new continuity.
I expect that if Power Girl does return, her origin will be revamped yet again.